C肽试剂盒有助于判定患者胰岛β功能

一.临床意义

C肽（C-Peptide）又称连接肽，是胰岛β细胞的分泌产物，它与胰岛素有一个共同的前体—胰岛素原。一个分子的胰岛素原经酶切后，裂解成一个分子的胰岛素和一个分子的C肽。正常情况下，人胰岛细胞主要分泌产生并释放到血液中的是胰岛素，在产生胰岛素的一系列的过程中，胰岛细胞首先合成胰岛素原。胰岛素原是一条很长的蛋白质链，胰岛素原在酶的作用下被分解为三段，前后两段又重新联接，成为有A链和B链组成的胰岛素，中间一段独立出来，称为C肽。

C肽与胰岛素以等分子数共存于分泌颗粒并同时释放至毛细血管循环中，且C肽不被肝脏破坏，半寿期较胰岛素明显为长，故测定血循环中c肽水平能反映β细胞合成与释放胰岛素功能。C肽的测定，有助于糖尿病的临床分型，胰岛细胞瘤的诊断及判断胰岛素瘤手术效果,判定患者的胰岛β细胞功能，鉴别低血糖的原因等。测定血清C肽的水平可以了解胰岛的分泌、代谢和胰岛B细胞的储备功能。

二.参考文献

1. Ashby, J. and Frier, B.: Circulating C-Peptide: Measurement and Clinical Applications.Annals of Clinical Biochemistry. 18:125, 1981
2. Beischer, W.: Proinsulin and C-Peptide in Humans. Hormones in Normal and Abnormal Human issues. Volume 3K, Fotherby and Pal, S., ed. (Berlin: Walter DeGruyter). pp. 1-43, 1983
3. Beyer, J., Krause V., Cordes V.: C-Peptide: Its Biogenesis, Structure, Determination and Clinical
Significance. Giornale Italiano di Chimica Clinica 4 Supp. 9:22, 1979
4. Bonger, A. and Garcia-Webb, P.: C-Peptide Measurement: Methods and Clinical Utility.CRC Critical Reviews in Clinical Laboratory Sciences. 19:297, 1984.
5. Blix, P. Boddie-Wills, C., Landau, R., Rochman, H. Rubenstein, A.: Urinary C-Peptide: An Indicator
of Beta-Cell Secretion under Different Metabolic Conditions.
Journal of Clinical Endocrinology and Metabolism. 54:574, 1982.
6. Rendell, M.: C-Peptide Levels as a Criterion in Treatment of Maturity-Onset Diabetes.Journal of Clinical Endocrinology and Metabolism. 57 (6): 1198, 1983
7. Horwitz, D., et al.: Proinsulin, Insulin and C-Peptide concentrations in Human Portal and Peripheral
Blood. Journal of Clinical Investigation. 55:1278, 1975
8. Horwitz, D., Kurzuya, H., Rubenstein, A.: Circulating Serum C-Peptide.The New England Journal of Medicine. 295:207,1976
9. Rendell, M.: The Expanding Clinical Use of C-Peptide, Radioimmunoassay.Acta Diabetologica Latina. 20:105, 1983
10. Heding, L. and Rasmussen, S.: Human C-Peptide in Normal and Diabetic Subjects.Diabetologica. 11:201, 1975
11. Canivet, B., Harter, M., Viot, G., Balgrac, N., Krebs, B.: Residual ?-Cell Function in Insulin-
Dependent Diabetes: Evaluation by Circadian Determination of C-Peptide Immuno reactivity. Journal
of Endocrinological Investigation. 3:107, 1980.
12. Starr, J., Horwitz, D., Rubenstein, A., Mako, M.: Insulin, Proinsulin and C-Peptide. Methods of
Hormone Radioimmunoassay 2nd Ed., Academic Press Inc., 1979
13. Rubenstein, A., Kuruya, H., Horwitz, D.: Clinical Significance of Circulating C-Peptide in Diabetes
Mellitus and Hypoglycemic Disorders. Archives of Internal Medicine. Vol. 137:625, May 1977.
14. Yalow, R., Berson, S.: Introduction and General Considerations. Principles of Competitive Protein
Binding Assays. Ch. 2, Eds. Odell, W. and Daugheday, W., J.B. Lippincott Co., Philadelphia, 1971

如需了解更多产品资料，请。