一.产品名称：Recombinant Human IL-17 (IL-17A)/Peprotech IL-17

二.Catalog Number:AF-200-17

三.Synonyms:IL-17, CTLA-8

四.Description:

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains. Manufactured using all non-animal reagents.

五.AA Sequence:

MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:Measured by its ability to induce IL-6 production by NHDF cells using a concentration range of 0.5-1.5 ng/ml.

九.Cross Reactivity:Human, Cow