名称 | Recombinant Human β-NGF |
型号 | |
更新时间 | 2023-09-24 |
特点 | β-NGF神经营养因子结构与BDNF,NT-3 NT-4相同。β-NGF强有力的神经营养因子,通过其受体β-NGFR信号,并在开发和保护中扮演着关键角色的感觉和交感神经系统。β-NGF还可以作为B淋巴细胞的生长和分化因素型和增强B细胞生存。使用所有无动物生产试剂。} |
产品展示 / PRODUCTS
- 详细内容
一.产品名称:Recombinant Human β-NGF/重组蛋白β-NGF
二.Catalog Number:AF-450-01
三.Synonyms:NGF-β
四.Description:
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity. Manufactured using all non-animal reagents.
五.AA Sequence:
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
六.Source:E.coli
七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.Biological Activity:
Assay 1:Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Assay 2:Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
九.Cross Reactivity:Chicken, Hamster, Mouse, Rat, Human
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