一.产品名称：Recombinant Human TPO

二.产地：美国Peprotech

三.Catalog Number:AF-300-18

四.Synonyms:Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF

五.Description:

TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of plaets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating plaets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Manufactured using all non-animal reagents.

六.AA Sequence:

SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL

七.Source:E.coli

八.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

九.Biological Activity:

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶ units/mg.

十.Cross Reactivity:Monkey, Mouse, Human, Rat, Human + Mouse