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当前位置:首页 > 产品展示 > Peprotech细胞因子 > 树突状细胞研究相关蛋白 > 重组蛋白Human sRANK Ligand

重组蛋白Human sRANK Ligand
名称 重组蛋白Human sRANK Ligand
型号
更新时间 2023-09-25
特点 RANKL和等级是TNF超科的成员发挥重要作用的配体和受体的规定特定的免疫和骨代谢。RANKL的表达在多种细胞包括成骨细胞、成纤维细胞、激活t细胞和骨髓基质细胞,可溶性sRANKL抑制osteoclastogenesis打断基质细胞之间的信号和监测祖细胞,从而导致骨骼和软骨的过度积累。重组人类sRANKL 20.0 kDa多肽包括TNF同源的RANKL地区(176氨基酸残基)。}
  • 详细内容

一.产品名称:Recombinant Human sRANK Ligand

二.Catalog Number:310-01

三.Synonyms:

soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)

四.Description:

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant human sRANKL is a 20.0 kDa polypeptide comprising the TNF homologous region of RANKL (176 amino acid residues).

五.AA Sequence:

MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to induce NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect is 10.0-25.0 ng/ml.

九.Cross Reactivity:Mouse, Rat, Human

十.www.peprotech.com

 

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